Mitoxantrone - Chemotherapy Drugs - Chemocare.
The most common side effects of mitoxantrone are: nausea, upper respiratory tract infections, hair loss (alopecia), diarrhea, interruption of menstruation, constipation, inflammation of the mouth (stomatitis).Mitoxantrone is a substrate for the drug transporter Breast Cancer Resistance Protein (BCRP). Voxilaprevir is a BCRP inhibitor. Sulindac: (Major) Due to the thrombocytopenic effects of mitoxantrone, an additive risk of bleeding may be seen in patients receiving concomitant anticoagulants, NSAIDs, platelet inhibitors, including aspirin, strontium-89 chloride, and thrombolytic agents.Mitoxantrone is also used to treat multiple sclerosis (MS), most notably the subset of the disease known as secondary-progressive MS. In the absence of a cure, mitoxantrone is effective in slowing the progression of secondary-progressive MS and extending the time between relapses in both relapsing-remitting MS and progressive-relapsing MS.
Mitoxantrone (Novantrone) is a cytotoxic agent that intercalates into DNA and inhibits topoisomerase II activity (see Table 20-4 for dosage schedule). It is a potent immune suppressor because of its cytopathic effects on replicating cells. In a study of RRMS and SPMS patients with incomplete recovery after attacks, mitoxantrone reduced the.Indications, dose, contra-indications, side-effects, interactions, cautions, warnings and other safety information for MITOXANTRONE.
Uses Mitoxantrone is used to treat leukemia and other cancers. It is also used to treat multiple sclerosis. It belongs to a class of drugs known as anthracenediones and works by slowing or stopping.
